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Structural organisation of p53 protein. The p53 393 amino acids comprise five main domains including acidic N-terminal region containing the transactivation domain and mdm2 binding site (1-50) a proline rich domain (6392) a central domain containing the sequence-specific DNA-binding domain (100-300) and c-terminal or tetramerisation domain consists of the oligomerisation domain Kali Kaya White Thai Kratom Effects (323-358) containing nuclear export signal and the regulatory domain (363-393) containing the nuclear localisation signals a nonspecific DNA binding domain that bind to damaged DNA and act as negative regulator of DNA binding of the central domain. November 2003 Cambridge University Press. Diagram showing mammalian cell cycle respond to DNA damage stimulus. ATR trigger the activation of a checkpoint that leads to cell cycle arrest or delay.
Cell lines 5. Chemicals and reagents 5. Cytological examination of MSE treated Cells 5. AAD double Kali Kaya White Thai Kratom Effects staining for apoptosis detection 5. Caspases enzyme assay 5.
Endogenous DNA damage mainly involves hydrolytic and oxidative reactions with DNA following the interaction between DNA reactive oxygen species (ROS) and water within the cells; whereas the environmental DNA damage refers to external physical or chemical agents that cause DNA damage Kali Kaya White Thai Kratom Effects (Friedberg et al 2006). The alkylating agents are examples of chemicals with the ability to damage DNA. They are electrophilic compounds kratom super indo kratom capsules dosage depression anxiety north attleboro with affinity for nucleophilic centres in organic Kali Kaya White Thai Kratom Effects macromolecules.
These cleave regulatory and structural molecules to execute the cell death programme (Ghobrial et al 2005). Extrinsic pathway The extrinsic pathway or death receptor pathway
triggers apoptosis via various pro-apoptotic protein receptors located on the plasma membrane of the cells (Fulda and Debatin 2006) which mainly belong to the tumour necrosis factor (TNF) receptor superfamily (Zapata et al 2001). These proteins include death receptors the membrane bound Fas ligand (FasL) the Fas complexes and the Fas associated death domain (FADD) and also the initiator caspase 8 and 10 (Ghobrial et al 2005). Fas is also known as APO-1 or CD95 (Krammer 1999). Other receptors which may be involved in this pathway include TNF R1 do they sell kratom at health food stores mountain home DR3 (Apo 2) DR4 (tumor necrosis factor related apoptosis-inducing ligand receptor or TRAIL R1) and DR5 or TRAIL R2
(Ashkenazi and Dixit 1998). Upon receiving the death stimulus the FasL interacts with inactive Fas complex and forms the deathinducing signalling complex which contains the adaptor protein Fas-associated death domain and also procaspases 8 and 10. This leads to activation of caspase 8 and further activation of downstream or executioner caspases 3 6 and 7 (Ghobrial et al 2005).